Historical Overview of Bioluminescent and Fluorescent Imaging in Biomedical Research

An exploration of the historical development and significance of bioluminescent and fluorescent imaging technologies in biomedical research. This topic delves into the evolutionary journey from rudimentary beginnings to cutting-edge innovations that have revolutionized the field. By discussing the pioneering figures and monumental milestones, readers will gain a comprehensive understanding of how these imaging techniques have been adopted and refined over time. Case studies of essential reagents such as luciferin potassium salt, caged luciferin probes, and ICG NHS ester will be highlighted, alongside the development of bioluminescent cell lines and Luc2 lentiviral particles. This overview serves to inform biomedical researchers, pharmaceutical scientists, and biotech professionals about the profound impact these technologies have had on preclinical studies and animal model research. By connecting past advancements with contemporary practices, this topic provides valuable insights for those seeking to leverage these imaging tools for groundbreaking research and innovation.